Bioinformatics:
“It is a computational approach with IT technology used to solve the problem of life sciences”.
Father and
mother of bioinformatics “Dr.Margarat Okley Dayhoff”.
Indian
father of bioinformatics “Dr.G.N. Ramachandran”.
a) Primary
database:-
· It is basic
type of database.
· Information
is direct submission.
· It is Low
annotated database.
(Annotation:-
It is attachment of biological information to newly discovered
sequences.)
· It is
Derived type of database.
· The
information derived from primary submission .
· It is highly
annotated database.
c)Composite database:-
· It is
mixture of primary and secondary database.
NCBI(National
Center for Biotechnology Information):-
URL:-(http://www.ncbi.nih.gov/Entrez/)
1) It is division of the National Library of Medicine (NLM) at the
National Institutes of Health (NLM),a federal agency of the US government.
2) The Entrez site for PubMed,Nucleotide,genome, protein and
structure database is being maintained in the USA.
3) The mission of the NCBI is to ensure that the growing body of
information from molecular biology and genome research is placed in the
public domain and is accessible freely
to all facets to all the scientific community in ways that promote scientific
progress.
URL:-http://www.ebi.ac.uk/)
1) It is poorly working in the field of bioinformatics.
2) It is a center for research and services in the field of
bioinformatics.
3) It is a non-profit academic organization in hinxton, Cambridge, UK.
4) It is a site for nucleotide and protein sequence, protein structure
and signature, seqs(SRS),and literature database.
5) The institute manages database of biological data including
nucleic acids, protein sequences and macromolecular structures.
6) EBI is large public institutes funded by the UK government.
SIB(Swiss
institutes of bioinformatics)
URL:-http://www.isb.sib.ch
1)The Switzerland Institute of bioinformatics(SIB) is an qusi- academic,
non-profit foundation whose mission is to promote research.
2)Development of databanks and computer technologies ,teaching and service activities in the field of bioinformatics,both individually with
international collaborators.
Nucleotide Sequence Database :-
1)The International Nucleotide Sequence Database Collaboratio(INSD) consiste nucleotide sequence database from three groups.
· DNA Databank of Japan(DDBJ) of National Institute
of Genetics,Japan.
· GenBank of
National Center for Biotechnology Information(NCBI),USA.
· The European
Molecular Biology Labs(EMBL)Data Library of European Bioinformatics
Institute,UK.
2)Databases
EMBL,GenBank and DDBJ are the primary nucleotide sequence database.
